Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms

Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers

BACKGROUND The transmembrane receptor guanylate cyclase-C (GCC) has been found to be expressed in colorectal cancers. However, limited data are available on GCC protein expression in non-colorectal gastrointestinal tumors and few studies have reported whether GCC protein expression was consistently preserved in synchronous primary and metastatic cancer tissues. METHODS GCC protein status was ...

MRI features of primary and metastatic mucinous ovarian tumors

Differentiating primary and extragenital metastatic mucinous ovarian tumours: an algorithm combining PAX8 with tumour size and laterality

AIMS Our aim was to analyse the utility of the algorithm combining PAX8 with clinicopathological characteristics (tumour size, laterality and patient age) in differentiating primary ovarian mucinous tumours (POMTs) from extragenital metastatic mucinous carcinomas involving the ovary (eMOMCs). METHODS AND RESULTS Immunohistochemical staining for PAX8 was performed on formalin fixed, paraffin emb...

Glycosylation of human receptor guanylyl cyclase C

Background Post translational modifications regulate several signalling pathways and glycosylation is emerging as a key player in this regulatory process. Glycosylation of cell surface receptors modulate the downstream signalling pathway and when altered causes a change in the normal physiology of the cell [1]. Guanylyl cyclase C (GC-C) belongs to a group of membrane bound receptors that produc...

Guanylyl cyclase C messenger RNA is a biomarker for recurrent stage II colorectal cancer.

BACKGROUND Patients with stage II colorectal cancer and no histologic evidence of lymph node invasion develop recurrent disease, presumably because of undetected micrometastases. Guanylyl cyclase C is expressed by intestinal and colorectal cancer cells but not by extraintestinal tissues or tumors. OBJECTIVE To examine the expression of guanylyl cyclase C messenger RNA (mRNA) in lymph nodes of...